导师类型

硕士研究生

办公地点

6教207室

职称/职务

讲师

电子邮箱

x.ou@sicau.edu.cn

研究方向

共用技术、人禽共患病毒性肝炎

学术、技术组织任职/头衔

四川省海外高层次留学人才、Frontiers in Immunology杂志审稿人、教育部学位中心研究生论文评审专家

教育背景及工作经历

2023.03-至今：环球360平台注册动物医学免疫学研究所，讲师

2019.07-2023.03：环球360平台注册预防兽医研究所，讲师

2017.09-2021.11：荷兰伊拉斯姆斯医学中心，医学博士

2012.09-2019.06：四川农业大学（直博），农学博士

2010.09-2012.06：黑龙江八一农垦大学，本科，农学学士

2008.10-2010.12：黑龙江大学，本科，工学学士

教学课程

生物信息

人才培养情况

担任硕士研究生导师，指导攻读科学硕士学位研究生5人，本科生2人。

科研项目

（近五年）

2020-01至2022-12干扰素α介导tRNA组改变在抗病毒基因翻译失常中的机理研究（10万）四川省科技厅，主持

2022-01至2024-12宿主tRNA调控鸭甲肝病毒在鸡胚细胞中翻译的分子机制（30万）国家自然科学基金，主持

主要论著、

代表性论文

1.Ou X, Cao J, Cheng A, Peppelenbosch MP, Pan Q. Errors in translational decoding: tRNA wobbling or misincorporation?Plos Genetics2019;15(3): e1008017.

2.Ou X, Ma B, Zhang R, et al. A simplified qPCR method revealing tRNAome remodeling upon infection by genotype 3 hepatitis E virus.FEBS Lett2020;594(12): 2005-15.

3.Ou X, Peng W, Yang Z, et al. Evolutionarily missing and conserved tRNA genes in human and avian.Infect Genet Evol2020: 104460.

4.Zhang R, Noordam L, Ou X, et al. The biological process of lysine‐tRNA charging is therapeutically targetable in liver cancer. 2021;41(1): 206-19.

5.Ou X, Yang Z, Zhu D, et al. Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2.Transbound Emerg Dis2021.

6.Ou X, Wang M, Mao S, et al. Incompatible Translation Drives a Convergent Evolution and Viral Attenuation During the Development of Live Attenuated Vaccine.Frontiers in Cellular and Infection Microbiology2018;8: 249-60.

7.Ou X, Mao S, Cao J, et al. Comparative analysis of virus-host interactions caused by a virulent and an attenuated duck hepatitis A virus genotype 1.PLOS ONE2017;12(6): e0178993.

8.Zhang R, Noordam L, Ou X, et al. The biological process of lysine-tRNA charging is therapeutically targetable in liver cancer.Liver Int2020;41(1): 206-19.

9.Mao S, Ou X, Wang M, et al. Duck hepatitis A virus 1 has lymphoid tissue tropism altering the organic immune responses of mature ducks.Transbound Emerg Dis2020.

10.Miao Z, Zhang S, Ou X, et al. Estimating the Global Prevalence, Disease Progression, and Clinical Outcome of Hepatitis Delta Virus Infection.The Journal of Infectious Diseases2019;221(10): 1677-87.

11.Cao J, Ou X, Zhu D, et al. The 2A2 protein of Duck hepatitis A virus type 1 induces apoptosis in primary cell culture.Virus Genes2016: 1-9.

12.Li Y, Qu C, Yu P, Ou X, Pan Q, Wang W. The Interplay between Host Innate Immunity and Hepatitis E Virus.Viruses2019;11(6): 541-60.

13.Zhu D, Chen H, Ou X, et al. Comparison of immunohistochemistry and Ziehl-Neelsen staining for detecting the distribution of Mycobacterium avium subsp avium in naturally infected domestic Pekin ducks (Anas platyrhynchos domestica).Veterinary medicine and science2019.

14.Wen X, Guo J, Sun D, et al. Mutations in VP0 and 2C Proteins of Duck Hepatitis A Virus Type 3 Attenuate Viral Infection and Virulence.Vaccines (Basel)2019;7(3).

15.Zhu D-K, Song X-H, Wang J-B, et al. Outbreak of Avian Tuberculosis in Commercial Domestic Pekin Ducks (Anas platyrhynchos domestica).Avian Diseases2016;60(3): 677-80.

16.Xie J, Zeng Q, Wang M, et al. Transcriptomic Characterization of a Chicken Embryo Model Infected With Duck Hepatitis A Virus Type 1.Frontiers in Immunology2018;9.

17.Mao S, Wang M, Ou X, et al. Virologic and Immunologic Characteristics in Mature Ducks with Acute Duck Hepatitis A Virus 1 Infection.Frontiers in Immunology2017;8.

18.Mao S, Ou X, Zhu D, et al. Development and evaluation of indirect ELISAs for the detection of IgG, IgM and IgA1 against duck hepatitis A virus 1.J Virol Methods2016;237: 79-85.

19.

授权专利、编著教材

用于人类基因组成熟tRNA谱检测的接头,引物组和试剂盒:授权号：ZL 201811302188.X.

社会服务

水禽病原检测与流行病学调查。